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Background Cardiovascular disease (CVD) is a major contributor to the burden of disease and the number one cause of death worldwide. From 1990 until today, more people have died from coronary heart disease than from any other cause. CVD is regularly treated with minimal or non-minimalinvasive offor on-pump cardiothoracic surgery and interventions related to the outcome of the surgical procedures are regularly evaluated in clinical trials, but heterogeneity in outcome reporting hinders comparison of interventions and limits the ability of research synthesis. This problem is encountered by core outcome sets (COS) that should be measured and reported – as a minimum – in all clinical trials for a specific clinical field.

A minimum core outcome set for clinical trials on non-minimal-invasive off- or on-pump cardiothoracic surgery