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Purpose Patient reported outcome measures (PROMs) are designed to assess patients’ perceived health states or health-related quality of life. However, PROMs are susceptible to missing data, which can affect the validity of conclusions from randomised controlled trials (RCTs). This review aims to assess current practice in the handling, analysis and reporting of missing PROMs outcome data in RCTs in relation to contemporary methodology and guidance.

The current practice of handling and reporting missing outcome data in eight widely-used PROMS in RCT publications: are we doing well?