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Core outcomes sets (COS) are an agreed minimum group of outcomes to measure in trials. Core information sets (CIS) are defined as the agreed minimum information required for clinical decision-making. Theoretically, these concepts should be closely aligned, however, there is no evidence that COSs adequately inform CISs. This study compared COS and CIS for colorectal cancer (CRC) surgery.

Core outcomes for randomized trials and core information for clinical decision-making: implications for outcome selection