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Results Using anchor based methods, the estimates using between-group difference were 0.56 at 12 weeks and 0.73 at 24 weeks and the estimates using within-patient change were 0.74 at 12 weeks and 0.90 at 24 weeks. All of the above estimates of the MCID exceed the minimum detectable change of 0.31. However, the results from distribution based methods were not in agreement, with half a standard deviation being 0.29. Further exploration of the results is currently being undertaken examining the effects of utilising the varying methodology. Conclusions A range of estimates for the MCID of the SCL-20 measure have been found. The estimates from the anchor-based approach are much higher than the target differences of approximately 0.3 previously used in clinical trials powered on the SCL-20, suggesting that the improvement regarded as meaningful by patients is much higher than expected.

Minimal clinically important difference (MCID) of the SCL-20 measure of depression severity in patients with cancer and major depression