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Background NICOLA-RT is using minor edits to invitation letters to assess their impact on potential participants’ decisions about joining a prospective study. Even small improvements in recruitment could produce important savings in cost and time. The elements in NICOLA-RT have been registered as SWAT (Study Within A Trial) 3, 4 and 5. These SWAT examine different approaches to recruitment and retention and ways to maximise these.

The NICOLA recruitment trial (NICOLA-RT): can you improve recruitment by making zero cost amendments to the invitation letter?