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Background  The results of preclinical studies suggest that baclofen may be useful in the treatment of stroke patients with persistent hiccups. This study was aimed to assess the possible efficacy of baclofen for the treatment of persistent hiccups after stroke.    Methods  In total, 30 stroke patients with persistent hiccups were randomly assigned to receive baclofen ( n  = 15) or a placebo ( n  = 15) in a double-blind, parallel-group trial. Participants in the baclofen group received 10 mg baclofen 3 times daily for 5 days. Participants assigned to the placebo group received 10 mg placebo 3 times daily for 5 days. The primary outcome measure was cessation of hiccups. Secondary outcome measures included efficacy in the two groups and adverse events.    Results  All 30 patients completed the study. The number of patients in whom the hiccups completely stopped was higher in the baclofen group than in the placebo group (relative risk, 7.00; 95% confidence interval, 1.91–25.62;  P  = 0.003). Furthermore, efficacy was higher in the baclofen group than in the placebo group ( P  < 0.01). No serious adverse events were documented in either group. One case each of mild transient drowsiness and dizziness was present in the baclofen group.    Conclusions  Baclofen was more effective than a placebo for the treatment of persistent hiccups in stroke patients.    Trial registration  Chinese Clinical Trials Register:  ChiCTR-TRC-13004554

Baclofen for stroke patients with persistent hiccups: a randomized, double-blind, placebo-controlled trial