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Background Significant numbers of studies struggle to recruit to target and request extension of time or additional funding. PREP is a study to develop a prediction model for adverse maternal and fetal outcomes in women with early onset pre-eclampsia. Pre-eclampsia is a condition in pregnancy associated with raised blood pressure and proteinuria and is one of the main causes of maternal and fetal mortality and morbidity. Accurate prediction of risks will aid clinicians in planning appropriate management.

Sample size in a prognostic study: prep (prediction of risks in early onset pre-eclampsia)