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Results Recruiters elicited treatment preferences similarly in all RCTs, but responses to them differed substantially. In the ProtecT RCT, recruiters explored participants’ preferences at length in four key ways: eliciting and acknowledging the preference rationale, balancing treatment views, empathising with the situation, and emphasising the need to keep an open mind and consider all treatments. Conversely in the other RCTs, treatment preferences were usually accepted by recruiters with little discussion and few patients randomised.

Recruiters to randomised trials can be trained to facilitate recruitment and informed consent by exploring patients’ treatment preferences