English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Background  Xerostomia, a subjective sense of dry mouth, is not generally regarded a disease despite its high prevalence among the elderly, and therefore continues to impair affected patients’ quality of life. In traditional Korean medicine, ‘ Yin-Deficiency ’ has been implicated in the pathogenesis of xerostomia among the elderly.  Yukmijihwang-tang  is a famous herbal prescription used to relieve ‘ Yin-Deficiency ’, and reportedly has antioxidant effects; therefore, it is postulated that  Yukmijihwang-tang  can be used to treat xerostomia in the elderly. However, to our knowledge, no clinical trial has been conducted on the effects of  Yukmijihwang-tang  on xerostomia. Thus, we designed a randomized clinical trial to investigate the effects and safety of  Yukmijihwang-tang  on xerostomia in the elderly. In addition, we will clarify the aforementioned assumption that ‘ Yin-Deficiency ’ is the major cause of xerostomia in the elderly by identifying a correlation between xerostomia and ‘ Yin-Deficiency ’.    Methods/Design  This randomized, double-blind, placebo-controlled trial will be carried out at two centers: Kyung Hee University Korean Medicine Hospital and Kyung Hee University Hospital at Gangdong. We will recruit 96 subjects aged 60-80 years who have experienced xerostomia for 3 months prior to participation. Subjects who present with score >40 on the visual analogue scale for xerostomia and unstimulated salivary flow rate under 0.3mL/min will be included and the randomization will be carried out by an independent statistician by using a random number creation program. The subjects and all researchers except the statistician will be blinded to the group assignment.  Yukmijihwang-tang  or placebo will be administered to each group for 8 weeks. The primary outcome is change in the scores for the visual analogue scale for xerostomia and the dry mouth symptom questionnaire from 0 to 8 weeks.    Discussion  It will be assessed whether  Yukmijihwang-tang  can be used as a new herbal treatment for xerostomia in the elderly by demonstrating its therapeutic effects in a well-designed clinical trial.    Trial registration  ClinicalTrials.gov Identifier:  NCT01579877

Yukmijihwang-tang for the treatment of xerostomia in the elderly: study protocol for a randomized, double-blind, placebo-controlled, two-center trial