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Objectives 1. To consider the challenges of recruiting and retaining medical patients in trials of complex interventions, that include ‘psychological’ components. 2. To discuss practical solutions to these challenges that ensure trials recruit to target and maximise outcome data collection. Examples are taken from three trials of complex interventions: SMaRT Oncology-2, SMaRT Oncology-3 and SMaRT Neurology-1.

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Recruiting and retaining medical patients in trials of complex interventions: practical experience of challenges and solutions in three multi-centre trials