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Background  Schizophrenia is a severe psychiatric disease characterized by a high heritability and a complex genetic architecture. Recent reports based on exome sequencing analyses have highlighted a significant increase of potentially deleterious  de novo  mutations in different genes in individuals with schizophrenia.    Findings  This report presents the mutation screening results of four candidate genes for which such  de novo  mutations were previously reported ( LRP1 ,  KPNA1 ,  ALS2CL  and  ZNF480 ). We have not identified any excess of rare variants in the additional SCZ cases we have screened.    Conclusions  This supports the notion that  de novo  mutations in these four genes are extremely rare in schizophrenia and further highlights the high degree of genetic heterogeneity of this disease.

Investigation of rare variants in LRP1, KPNA1, ALS2CL and ZNF480 genes in schizophrenia patients reflects genetic heterogeneity of the disease