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Background  Several studies have hypothesized that genes regulating the components of the serotonin system, including  serotonin transporter  ( 5-HTTLPR ) and  serotonin 1 B receptor (5-HT1B),  may be associated with alcoholism, but their results are contradictory because of alcoholism’s heterogeneity. Therefore, we examined whether the  5-HTTLPR  gene and  5-HT1B  gene  G861C  polymorphism are susceptibility factors for a specific subtype of alcoholism, antisocial alcoholism in Han Chinese in Taiwan.    Methods  We recruited 273 Han Chinese male inmates with antisocial personality disorder (ASPD) [antisocial alcoholism (AS-ALC) group ( n  = 120) and antisocial non-alcoholism (AS-N-ALC) group ( n  = 153)] and 191 healthy male controls from the community. Genotyping was done using PCR-RFLP.    Results  There were no significant differences in the genotypic frequency of the  5-HT1B G861C  polymorphism between the 3 groups. Although AS-ALC group members more frequently carried the  5-HTTLPR S/S, S/L   G   ,  and  L   G   /L   G   genotypes than controls, the difference became non-significant after controlling for the covarying effects of age. However, the  5-HTTLPR S/S, S/L   G   ,  and  L   G/   L   G   genotypes may have interacted with the  5-HT1B G861C C/C  polymorphism and increased the risk of becoming antisocial alcoholism.    Conclusion  Our study suggests that neither the  5-HTTLPR  gene nor the  5-HT1B G861C  polymorphism alone is a risk factor for antisocial alcoholism in Taiwan’s Han Chinese population, but that the interaction between both genes may increase susceptibility to antisocial alcoholism.

Interaction between Serotonin Transporter and Serotonin Receptor 1 B genes polymorphisms may be associated with antisocial alcoholism