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Background  Recent research has implicated that mutations in the neurexin-1 ( NRXN1 ) gene on chromosome 2p16.3 might play a role in schizophrenia, autism, and nicotine dependence. In order to explore the association of  NRXN1  polymorphisms with schizophrenia, we made a case-control association study in Chinese Han population.    Methods  We examined six tag single nucleotide polymorphisms (SNPs) spanning 116.7 kb of  NRXN1  in 768 schizophrenic patients and 738 healthy control subjects. The association of  NRXN1  polymorphisms with schizophrenia and the age-at-onset of this disease were explored.    Results  Our results showed that four SNPs of  NRXN1  gene were significantly associated with schizophrenia (rs10490168: G > A,  p  = 0.017; rs2024513: A > G,  p  = 0.006; rs13382584: T > C,  p  = 0.009; and rs1558852: G > A,  p  = 0.031). Furthermore, the association of SNP rs2024513 with schizophrenia remained significance after the Bonferroni correction. Haplotypes consisting of above six SNPs also showed significantly associated with schizophrenia (global chi-square = 14.725,  p  = 0.022). A protective haplotype AGTGCA remained associated with schizophrenia, even after 10,000 permutation tests (empirical  p -value = 0.043). However, we did not find any association with age-at-onset of schizophrenia with  NRXN1  polymorphisms.    Conclusions  Our findings suggest that  NRXN1  might represent a major susceptibility gene for schizophrenia in Chinese Han population.

A case-control association study of NRXN1 polymorphisms with schizophrenia in Chinese Han population