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In total, 2013 patients, mean age 39.7 ± 12.5, were included in the study, 54.4% of which were males and 45.6% females. Most of the patients were unmarried (64%), living with their family (64.4%) and unemployed (54.2%) at the time of screening. After treatment change to another antipsychotic agent positive symptoms significantly decreased by 23.6% (p < 0.005), negative symptoms remained unchanged and other symptoms significantly decreased by 15.9% (p < 0.05). Illusions, delusions and disorganised speech/thinking, were the positive symptoms with the most profound decrease (14% p < 0.001, 13.1% p < 0.001 and 5.4% p < 0.005 respectively). No significant changes were observed in affective flattening, aggressiveness, sleep and cognitive disorders. All administered antipsychotic treatments were associated with significant decrease in positive symptoms, with ziprasidone, olanzapine, rispesridone, quetiapine, aripiprazole, and aminosulpride showing more than 20% decrease (p < 0.001). Ziprasidone, aripiprazole, cloazapine, quetiapine and aminisulrpide were associated with decrease in negative treatments, however only ziprasidone and ariprazole decreases reached significance (p < 0.01 and p < 0.02 respectively. All agents, showed significant decrease in other symptoms (p < 0.001).

Evolution of symptoms with antipsychotic treatment in schizophrenic outpatients in Greece: the GRACE Study