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Materials and methods Participants were 48 BD, 21 BDMD and 70 controls. All participants underwent assessment of Full Scale IQ (WAIS-R), working memory (N-back), initiation and inhibition (HSCT), cognitive set shifting and mental flexibility (WCST), memory (WMS-III), decision making and judgement (IGT), sustained attention (CPT) and interference (SCWT). Confirmation of diagnosis was made using Structured Clinical Interview for DSM-IV (SCID-I/II) and symptomatology was assessed with the HDRS and YMRS.

Endophenotypic markers of bipolar disorder (BD) in probands and their first degree relatives with major depression (MD)