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Background The effect of addictive substances on brain’s utilizing mechanisms of glucose for neuronal functions are poorly understood. To identify novel neurobiological mechanisms of addiction (precisely on brain glucose metabolism), we developed a model that incorporates the b-cell and the fishbone models of glucose metabolism and examined the role of various psychostimulants (alcohol, cocaine, heroine) on the functions of the model. The abbreviation “CoBBGluM model” means Convergence (incorporation of the b-cell and the fishbone models) model of Blood-Brain Glucose Metabolism.

A model that might better explain the effects of addiction substances on the nervous system: the CoBBGlum model