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Background Inflammatory bowel diseases (IBD), including ulcerative colitis (UC) and Crohn’s disease (CD), belong to the autoimmune disorders in the sense that an excessive response of the immune system(both innate and acquired) towards commensal microbial flora of the intestinal mucosa is involved in their pathogenesis. The progress of IBD is unknown, characterized by periods of exacerbation and quiescence. Depression and anxiety seem to coincide with relapse of IBD and further research is needed for the clarification of this correlation.

Possible correlations between the psychological state and excessive innate immunity responses in ulcerative colitis