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Background Abnormal protein expression of N-methyl-D-aspartate (NMDA) receptors essential subunits (NR1, NR2) and of associated post-synaptic density proteins (PSD-95, PSD-93) were observed in schizophrenic patients (postmortem studies) [1,2]. NMDA receptors containing NNR2A/B subunit associate in vivo at synapses with PSD-93 and PSD-95 [3]. In the present study, we have silenced the expression of NR1 and/or NR2 proteins in vivo with the goal of assessing the influence of that protein’s alteration on the prepulse inhibition of acoustic startle reaction (PPI) and on the expression of related PSD-95/PSD-93 proteins.

Expression of NR1 subunit of NMDA receptor and PSD-93/95 in rat hippocampus affected by NR1/NR2 antisense oligodeoxynucleotide