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The role of the immune system in the neurobiological and pathophysiological mechanisms mediating psychiatric symptomotology and cognitive functioning has attracted increasing attention in recent years. This role is exemplified in the case of patients with chronic viral infections secondary to substance use disorders and in the use of cytokines as antiviral therapies [e.g., interferon-alpha therapy for hepatitis C viral (HCV) infection]. In particular, the recent methamphetamine epidemic in the United States has highlighted the risk of contracting human immunodeficiency viral (HIV) and HCV infections. Not only do substance use disorders increase the risk of contracting HIV or HCV, they have also been associated with decreased antiviral therapy utilization and virological suppression.

Brain-Immune Interactions: the role of cytokines in depression and substance use disorders