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The advent of second generation antipsychotic drugs is nowadays considered as a hallmark in the history of psychopharmacology. The clinician treating psychotic disorders is today “backed” by guidelines which present as a first choice drug one belonging to the group of second generation antipsychotics. Certainly the so called “second generation group antipsychotics” present a dauntly interesting side effects profile, where compared with the conventional antipsychotic group, notably on aspects such as EPS, higher efficacy in the treatment of negative symptoms and raise hopes in coping with an alleged cognitive deficit related with the psychotic disorder. Yet the first enthusiasm with which clinicians encompassed the use of the “group” soon gave place to a certain skepticism. Side effects such as weight gain, diabetes and dyslipidemia, previously neglected in clinical practice and absent in clinical literature started to concern clinicians in relation with the use of the “new” drugs.

Informed pharmacotherapy of psychosis: carrying research results to everyday clinical practice