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Background Delusional Misidentification Syndromes (DMSs) have been observed in a variety of psychiatric and other medical conditions but they seem to be strongly associated with schizophrenia since they occur predominantly in the context of paranoid schizophrenia. Previous studies about a neuropsychological relationship between DMSs and schizophrenia have implicated cognitive functions performed by bilateral frontal and right hemisphere in both schizophrenia and DMS, but there are mainly case reports, lacking the appropriate controls. Aim of the present study was to investigate whether DMS in paranoid schizophrenia is mediated by a distinct neuropsychological substrate indicative of differential bilateral frontal and right hemisphere dysfunction.

Neuropsychological association between paranoid schizophrenia and delusional misidentification syndromes: an in between subjects design