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Background It has been suggested that histamine have modulatory influence on anxiety-related behaviors both in animals and humans. On the other hand, ventral hippocampus (VHC) may be an important brain site in the modulation of fear or anxiety. In the present study, the effects of bilateral intra-VHC injections of histamine on anxiety-related behavior have been investigated in morphine-sensitized and naive rats using a plus-maze model.

Influence of morphine-induced sensitization on histamine-induced anxiety like behaviors in the elevated plus-maze test