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increase in time spent in the close arms (P<0.05) with increases in ethological type of exploratory behaviors (head streached, P<0.05; upward exploratory behavior, P<0.001; and self-grooming P<0.05), compared to the SI rats reared barren environment. NMDA receptor blockade attenuates the effects of physical enrichment in the EPM. Conclusions These findings indicate that NMDA receptor blockade in the last maturation period of brain development is implicated in forming multiple associations with environment.

annals of general psychiatry

Effects of NMDA receptor blockade in early developmental period on emotional behaviors in adult social isolated rats reared in physical barren and enriched conditions