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Background There are several studies indicating that histamine may elicit modulatory influence on anxiety-related behaviours both in animals and humans [1-4]. The activity of histaminergic pathways subserving corticolimbic structures is enhanced in response to fear-evoking and other stressful stimuli. The nucleus accumbens (NAc) belongs to the mesolimbic system and is a major component of the ventral striatum of rat. The elevated plus maze (EPM) was used to assess anxiolytic behaviour.

The effects of histaminergic system in nucleus accumbens of rats in the plus-maze test of anxiety-like behaviours