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Materials and methods Fifty-eight Korean children with ASD (47 boys (81.0%), mean age, 5.5 ± 4.1 years old) were enrolled from the outpatient clinic at a general hospital in Seoul, Korea. In addition, 46 family trios, each consisting of an affected child with ASD and that child's biological parent, were recruited. Eighty-six healthy control subjects (71 males (82.6%), mean age, 33.6 ± 9.3 years old) were also recruited through advertisements in local newspapers. TDT was applied to analyze the preferential intergenerational transmission of GABRB3 microsatellite in 46 complete trios.

annals of general psychiatry

Association of the GABRB3 microsatellite marker in gamma-aminobutyric acid-A receptor beta 3 subunit gene with autism spectrum disorders in Korean trios