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Materials and methods A sample of 451 persons (men 237, women 214) aged 60–64 drawn from a large community sample underwent brain MRI scans. WMHs on T2-weighted FLAIR MRI scans were measured and topographically mapped using an automated procedure. Subjects were assessed for physical health, cognitive function, putative risk factors for cerebrovascular disease and Apolipoprotein E ε4 (Apo E4) genotyping. Regression analyses were used to examine the effect of WMHs on physical and cognitive function, and the role of risk factors for total, deep (DWMHs) and periventricular (PVWMHs) hyperintensities.

Why do women have more white matter hyperintensities? Sex differences in the extent, aetiology and consequences of leukoaraiosis