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Background The Paced Auditory Serial Addition Test (PASAT) is being increasingly used as a psychometric tool particularly as a part of the Multiple Sclerosis Functional Composite Measure. Previous studies reported the relationship between T2 lesion load on brain MRI and PASAT scores. The effect, however, of T1 hypointense lesions, which are thought to reflect destructive aspects of the disease process, and brain atrophy remains unexplored.

The paced auditory serial addition test in multiple sclerosis patients: the effect of brain atrophy and T1 lesion load