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Background The toxic effects of lead are well-known. The nervous system and the haem synthesis are the two main points where the symptoms present themselves first. The common feature is that lead replaces Zn, Cu, Fe, Ca cations or inhibits the enzymes related to these cations. The correlation between lead and essential metal (Zn, Cu, Fe, Ca) concentration in blood has been studied for several years. Not only these cations but some related proteins can regulate blood lead levels. We investigated essential metals in connection with lead detoxification, we reported that ingestion of calcium and iron in drinking water, may decrease intestinal absorption of Pb in rat wistar and we attempted to relate the behavioral effects of lead to neurotransmission.

Chronic oral administration of calcium and iron to accelerate body lead detoxification after chronic lead exposure in Wistar rats