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Background The dopaminergic system is involved in the emotional and motivational behavior as well as the mechanisms underling the effects of typical antidepressants; thus, the activity of dopamine receptors may participate the psychological kinetics of mood disorders, for example the depression. The aim of this study was to elucidate the role of dopamine D1 and D2 receptors in the development of behavioral learned helplessness, one of the depression animal models.

Role of the dopamine receptors in the development of learned helplessness