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Background Repetitive transcranial magnetic stimulation (rTMS) noninvasively triggers action potentials in underlying brain cortex intended for therapeutic benefit. Currently marketed for refractory depression, rTMS is under investigation for treating several neurological conditions including pain. Facial neuropathic pain (NP) appears to respond well to rTMS [1]. The primary motor cortex (M1) is established as the best site to stimulate to relieve pain, but the best target within M1 remains unknown [1,2]. MRI guidance of rTMS permits repeated precise application to specific targets. The aim of this study was to compare pain relief obtained by applying MRI-guided rTMS to the M1 representation of subjects’ painful face vs. to adjacent M1 cortex innervating their non-painful hand.

molecular pain

Repetitive transcranial magnetic stimulation (rTMS) of the primary motor cortex for treating facial neuropathic pain – preliminary results of a randomized, sham-controlled, cross-over study