English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Tools annual

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Presents the access of premium content as premium feature

Premium Content

Global: Zendy Plus annual

Global: Zendy Free Plan

Background  Genetic causes of exaggerated or reduced pain sensitivity in humans are well known. Recently, single nucleotide polymorphisms (SNPs) in the gene  P2RX7 , coding for the ATP-gated ion channel P2X 7,  have been described that cause gain-of-function (GOF) and loss-of-function (LOF), respectively of this channel. Importantly,  P2RX7  SNPs have been associated with more or less severe pain scores in patient suffering of post-mastectomy pain and osteoarthritis.    Results  The functional consequences of some  P2RX7  SNPs (rs208294 (His155Tyr), rs1718119 (Ala348Thr) and rs3751143 (Glu496Ala)) were studied in recombinant cells in vitro. Our findings suggest a correlation between GOF and LOF of P2X 7  and actual channel protein expression. Both channel and pore function for these mutant P2X 7  receptors changed in parallel to protein levels. On the other hand, the mutant receptors did not differ in their sensitivity to known P2X 7  agonists and antagonists. We further demonstrated that in patients with diabetic peripheral neuropathic pain (DPNP), the presence of the GOF SNPs rs208294 (His155Tyr) and rs1718119 (Ala348Thr) is associated, in females, with higher pain intensity scores.    Conclusions  Our present results confirm the physiological relevance of some of the SNPs in the  P2RX7  gene and show that the presence of these genetic variants correlates with pain sensitivity also in a diabetic neuropathic pain patient population.

Gain and Loss of Function of P2X7Receptors: Mechanisms, Pharmacology and Relevance to Diabetic Neuropathic Pain

Gain and Loss of Function of P2X₇Receptors: Mechanisms, Pharmacology and Relevance to Diabetic Neuropathic Pain