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Background The correlation of hypertension with vascular dementia has long been established and it is becoming increasingly clear that hypertension is also a reversible risk factor in the development of Alzheimer’s dementia (AD). Aging, AD and hypertension are major determinants of cognitive dysfunction which are associated with profound alterations in the structure and function of cerebral blood vessels. The aim of the present work is to analyze cerebrovascular blood flow in the middle cerebral artery (MCA), the integrity of blood to CSF barrier (BCB), choroid plexus (CP) structure and protein secretion as well as cerebrospinal fluid (CSF) protein composition.

cerebrospinal fluid research

Long-term effects of arterial hypertension on the choroid plexus, blood to cerebrospinal fluid barrier and CSF proteins and their involved in certain types of dementia