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Background In spina bifida aperta (SBA), movements caudal to the meningomyelocele (MMC) are present in utero, but they disappear shortly after birth. Insight in onset and progression of movement loss is therapeutically relevant. Determination of muscle echogenicity (or density (MD)) is used to estimate onset and progression of various neuromuscular disorders in children. In prenatal SBA, we hypothesized that MD assessment could indicate onset and progression of muscle damage in relation to movement loss. Objective: To estimate onset and progression of muscle changes in fetal SBA by MD assessment.

Muscle echogenicity is increased in fetuses with spina bifida aperta