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Background Hydrocephalus is a disorder characterized by brain ventricular dilation and excess of cerebrospinal fluid (CSF), in many cases its etiopathic origin is acquired as: post-hemorrhage, meningitis and tumours. But, there is no attributable cause in 45% of hydrocephalus cases and foetal hydrocephalus due to aqueductal stenosis is one of the two main groups of non acquired or congenital hydrocephalus, however whether narrowing of the aqueduct of Sylvius is cause or consequence of hydrocephalus is discussed by different authors. Anyhow, most investigators describe an alteration in the SCO and certain circumventricular structures in the hydrocephalus, that can even occur before hydrocephalus is present and of course before the aqueduct stenosis. The objective of the present work is to investigate probable changes in the protean composition of the CSF in perinatal hydrocephalus and to analyze, in those liquids, the presence of soluble proteins that are immunoreactive or antibodies against Reissner fibre proteins and human foetal SCO extracts

Protein changes in the cerebrospinal fluid of the different types of perinatal human hydrocephalus