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Materials and methods The reproductive history of 152 mothers with spina bifida offspring was investigated. Mothers were selected retrospectively from a publicly maintained registry of spinal cord disabled individuals. Only mothers who knew their blood type with singleton pregnancies were included. Primiparas (19 mothers) were included. All responses were by self-report. Lesion level was determined by muscle action against gravity and was divided into upper (thoracic) and lower (lumbar and sacral). Statistical tests included χ-square, Fisher's exact and student's t with rejection of the null hypothesis at the 0.05 level.

Epidemiologic evidence linking ABO and Rh blood groups in the mother with neural tube defect lesion level in the child