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Materials and Methods In 20 adult SD-rats kaolin hydrocephalus was induced and immunostaining of neurofilament (NF68), neuronal nitric oxide synthase (NOS), synaptophysin (SYN38) and heat-shock-protein (HSP70) was performed at 2,4,6 and 8 weeks (5 controls). In further 30 hydrocephalic rats, a polyethylene-catheter (PE 10) was placed into the lateral ventricle allowing the CSF to be drained subcutaneously into the neck. Each 15 rats were shunted at 1 week (early) and at 3 weeks (late). Both groups were then investigated at 1,3 and 5 weeks of shunt implantation (5 sham). Immunoreactivity (%) was analysed with the aid of computerized image-analysis; P < 0.01.

cerebrospinal fluid research

Incomplete reversibility of selective hippocampal response after early and delayed shunting in adult kaolin-hydrocephalus – implications for early shunt treatment