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Clinical background To determine the incidence of elevated CSF pressure (CSFP) in patients with a clinical diagnosis of AD. Several studies have documented the coexistence of AD pathology in NPH patients at a rate greater than chance. There has been no corollary study addressing the incidence of NPH among patients with AD. We report elevated CSFP, consistent with NPH, in a small subset of AD patients (ADNPH) enrolled in an ongoing clinical trial of chronic lowflow CSF drainage, via a novel VP shunt, in AD.

Probable NPH in patients with clinical AD: further support for the AD-NPH syndrome and CSF circulatory failure