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Background Changes in CSF circulation, as seen in adult chronic hydrocephalus (CH), can result in changes in CSF content, neurodegeneration, a loss of neurological function, and death. The microtubule-associated protein, Tau has been implicated in the pathogenic mechanisms of dementia and neurodegenerative disorders through accumulation in CSF and brain. To date, the relationship between the CSF circulation changes in CH and the levels of tau in CSF and brain has not been studied.

Changes in pTau in CSF and brain relating to chronic hydrocephalus