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Materials and Methods Ten patients with idiopathic NPH (mean age 69 years) underwent a CSF infusion study via a previously implanted right frontal ventricular catheter connected to a subcutaneous reservoir. CBF was measured by H215O PET at baseline and then during the steady-state plateau of raised ICP. The PET images were co-registered to 3D structural T1-weighted MR images. In 10 healthy normal volunteers (mean age 45 years) image acquisition and reconstruction were accomplished in the same manner, except that only a baseline CBF determination was performed.

Pattern of regional white matter CBF in normal pressure hydrocephalus during infusion test