English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Background  Tissue concentrations of fatty acids (FAs) and genetic variations are well-known factors which affect the cardiovascular disease (CVD) risk. The objective was to examine whether the genetic variability of 20 candidate genes and red blood cells (RBCs) percentage of total  n -3 polyunsaturated fatty acids (PUFA), a biomarker of dietary  n -3 PUFA intake, modulate lipid related CVD risk factors in the Inuit population.    Methods  Data from the Qanuippitaa Nunavik Health Survey (n = 553) were analysed via multivariate regression models with 40 known polymorphisms, RBCs percentage of  n -3 PUFA, and the interaction term to take into account the effect on plasma lipid and apolipoporotein levels.    Results  Individuals being heterozygotes for  CETP  C-4502T (rs183130) or G-971A (rs4783961) together with higher  n -3 PUFA had lower triacylglycerol (TG) concentrations compared to homozygotes for the minor allele. Further, effects of a stronger beneficial association between  n -3 PUFA in RBCs and plasma lipid parameters- including lower total cholesterol (TC), lower low-density lipoprotein cholesterol (LDL-C) or higher high-density lipoprotein cholesterol (HDL-C) concentrations- were associated with  AGT  M235T (rs699) TT genotype,  CETP  G-971A (rs4783961) AG genotype, T allele carriers of  CETP  C-4502T (rs183130), and T allele carriers of  CETP  Ile405Val (rs5882). In contrast, higher  n -3 PUFA in RBCs were associated with adverse lipid profiles- including increased LDL-C, increased apolipoprotein B100 or decreased HDL-C concentrations- in G allele carriers of the  APOA5  -3 A/G (rs651821), C allele carriers of  APOA5  T-1131C (rs662799), G carriers of  APOC3  SstI (rs5128) and G carriers of  APOA4  Asn147Ser (rs5104).    Conclusion  Overall, these results suggest that percentage of total  n -3 PUFA of RBCs are associated with lipids related CVD risk factors conferred by genetic variations in the Inuit population.

Omega-3 fatty acids, polymorphisms and lipid related cardiovascular disease risk factors in the Inuit population