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Background  A blunted muscle protein synthetic response to protein ingestion may contribute to the age related loss of muscle tissue. We hypothesized that the greater endogenous insulin release following co-ingestion of carbohydrate facilitates post-prandial muscle protein accretion after ingesting a meal-like bolus of protein in older males.    Methods  Twenty-four healthy older men (75±1 y) were randomly assigned to ingest 20 g intrinsically L-[1- 13 C] phenylalanine-labeled casein protein with (PRO-CHO) or without (PRO) 40 g carbohydrate. Ingestion of specifically produced intrinsically L-[1- 13 C] phenylalanine labeled protein allowed us to assess post-prandial incorporation of dietary protein derived amino acids into muscle protein. Blood samples were collected at regular intervals, with muscle biopsies being obtained prior to and 2 and 6 h after protein ingestion.    Results  Plasma glucose and insulin concentrations showed a greater increase in PRO-CHO compared with PRO ( P <0.001). Muscle protein-bound L-[1- 13 C] phenylalanine enrichments tended to increase to a greater extent in PRO-CHO compared with PRO during the first 2 h after protein ingestion (0.0072±0.0013 vs 0.0046±0.010 MPE, respectively;  P =0.13). However, 6 h after protein ingestion, differences in muscle protein-bound L-[1- 13 C] phenylalanine enrichments were no longer observed between experiments (0.0213±0.0024 vs 0.0185±0.0010 MPE, respectively;  P =0.30).    Conclusions  This study shows that carbohydrate ingestion may accelerate, but does not further augment post-prandial incorporation of dietary protein derived amino acids into muscle protein in healthy elderly men.

Carbohydrate co-ingestion with protein does not further augment post-prandial muscle protein accretion in older men