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Background  The CD5 protein antagonizes phosphorylation events downstream of T cell receptor (TCR) engagement to decrease T cell responsiveness. CD5-negative T cell clones respond preferentially over their CD5 +  counterparts against cells with low human histocompatibility-linked leukocyte antigen (HLA) levels. In human immunodeficiency virus type 1 (HIV-1) infection, CD5 - CD8 +  T cells increase in prevalence with disease progression.    Methods  To investigate potential causes of this expansion of CD5 - CD8 +  T cells in HIV-1 infection, we compared CD5 expression on CD8 +  T cells reactive against HIV-1 peptides, common viral peptides and a self peptide that together span a broad range of TCR avidities in the context of the common HLA-A2 class I restriction molecule. Following stimulation, CD5 expression on peptide-specific CD8 +  T cells was assessed by flow cytometry.    Results  In healthy controls, there was no significant difference in the CD5 +  percentage of CD8 +  T cells specific for common viral peptides, but a lower percentage of those responding against a common self peptide expressed CD5. The same relationship occurred in HIV-infected individuals, however, a lower percentage of HIV peptide-specific CD8 +  T cells than other viral peptide-specific CD8 +  T cells expressed CD5. In terms of overall CD5 expression level at the peptide-specific responder population level, HIV-specific CD8 +  T cells resembled those responsive against the self peptide, despite much higher avidity TCR/HLA/peptide interactions.    Conclusions  This deficit in CD5 expression selective for HIV-specific CD8 +  T cells is consistent with  in vivo  adaptation to low avidity HIV peptide variants and has potential consequences for CD8 +  T cell expansion, cross-reactivity and autoreactivity.

aids research and therapy

Greater frequency of CD5-negative CD8+ T cells against human immunodeficiency virus type 1 than other viruses is consistent with adaptation to antigenic variation