English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Background   Chlamydia pneumoniae  is an obligate intracellular respiratory pathogen for humans. Infection by  C. pneumoniae  may be linked etiologically to extra-respiratory diseases of aging, especially atherosclerosis. We have previously shown that age promotes  C. pneumoniae  respiratory infection and extra-respiratory spread in BALB/c mice.    Findings  Aged C57BL/6 mice had a greater propensity to develop chronic and/or progressive respiratory infections following experimental intranasal infection by  Chlamydia pneumoniae  when compared to young counterparts. A heptavalent CTL epitope minigene (CpnCTL7) vaccine conferred equal protection in the lungs of both aged and young mice. This vaccine was partially effective in protecting against  C. pneumoniae  spread to the cardiovascular system of young mice, but failed to provide cardiovascular protection in aged animals.    Conclusions  Our findings suggest that vaccine strategies that target the generation of a  C. pneumoniae -specific CTL response can protect the respiratory system of both young and aged animals, but may not be adequate to prevent dissemination of  C. pneumoniae  to the cardiovascular system or control replication in those tissues in aged animals.

Effect of age and vaccination on extent and spread of Chlamydia pneumoniae infection in C57BL/6 mice