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Background The gp120 CD4 binding site (CD4bs) and coreceptor binding site (CoRbs) are two functionally conserved elements of the HIV-1 envelope glycoproteins (Env). We previously defined the presence of CD4bs neutralizing antibodies (nAbs) in the serum of an HIV-1 infected individual and subsequently isolated the CD4bs-specific monoclonal antibodies (mAbs) VRC01 and VRC03 from the memory B cell population. From the same patient sera, we detected that there was also a fraction of potent nAbs specific for elements of the Env CoRbs by differential protein adsorption followed by neutralization analysis.

HIV-1 neutralizing antibodies display dual specificity for the primary and coreceptor binding sites and preferential recognition of fully-cleaved Env