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Results Newly isolated VHH from multiple immunized llamas also have broad and potent HIV-1 neutralization activity. J3 targets HIV-1 via the CD4-binding site and neutralization is seen when J3 is used in combination with VHH targeting other Env epitopes. VHH-human FC fusion heavychain only antibodies (VHH-FC) have been constructed and J3 activity is not only preserved in this context but enhanced.

Broad and potent neutralization of HIV-1 by human-llama fusion antibodies derived from immunized llamas