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Background The RV144 trial has rekindled interest in defining the epitopes responsible for the neutralization of CRF01_AE (clade E) viruses. In this study we used a novel method, swarm analysis, to map epitopes on Thai viruses recognized by broadly neutralizing (bN) antibodies in HIV+ sera. Swarm analysis relies on the swarm of closely related quasi-species that evolve in each HIV+ individual. In these studies we analyzed the bN activity in sera from elite neutralizers (ENs) against Thai viruses.

Mapping epitopes on CRF01_AE viruses recognized by broadly neutralizing antibodies in sera from elite neutralizers from North America and Thailand