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Results The finding of reactive determinants ranges from 30 to 240 amino acids, which allows some conformational determinants being evaluated as a major technical improvement. The antigen profile of the two types of vaccineinduced sera before viral challenge shared two dominant domains that concentrated at the V1V2 stem of gp120 and the ecto-domain of gp41. Interestingly, using a FACSbased antibody binding assay, there were no significant differences of titer and MFI of anti-V1V2 antibodies between the two vaccination groups, suggested a minimal role of these antibodies in controlling viral replication post SIVmac239 challenge. A major distinct domain, however, was identified near the V3 loop and the main CD4 binding region which was significantly recognized by the immune serum of the effective vaccination regimen but not of the non-effective vaccination regimen or natural SIV infection. Unexpectedly, the anti-V1/V2 antibody responses were shifted to the ecto-gp41 region when infected macaques developed AIDS.

Comprehensive mapping of SIVmac239 envelope antigenic determinants recognized by specific polyclonal antibodies in vaccinated and/or infected macaques