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Background Needle-free delivery has the potential to enhance vaccine efficacy and safety, as well as facilitate cost-effective global vaccine distribution and storage. To this end, microneedle arrays provide the ability for pain-free, safe, and convenient materials delivery through disruption of the outer layers of the skin to access potent immunecompetent cell populations residing within the epidermal/dermal tissues.

Engineered microneedle arrays for transcutaneous HIV vaccine delivery