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Background Recent research highlight that newly synthesized HIV-1 capsid protein is required to induce dendritic cell activation through a pathway involving interaction with peptidyl-prolyl cis-trans isomerase cyclophilin A (CYPA),which subsequently induce an antiviral type I interferon response and activation of T cells. Previous studies also revealed HIV Gag-CYPA interaction inhibited recognition by host restriction factors. In another perspective, the inhibition effect might be benefit for HIV Gag immunogenicity. Consequently, we assume CYPA might be a potential genetic adjuvant co-inoculation with HIV-1 Gag DNA vaccine, which not only circumvent the restriction of host factors, but also activate dendritic cell and enhance adaptive immune response.

CYPA, a novel and potential genetic adjuvant enhanced HIV-1 DNA vaccine immunoreactivity