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Methods Treg and CD8+ T cells were isolated from healthy donors (n=10) (HD) and chronically HAART treated HIV+ pt enrolled in a phase I/II IL-7 INSPIRE study (n=6X) (Levy et al, CID, in press). Treg subpopulations (naive CD45RA+FoxP3++CD45RA+CD25++CD127+/-, memory (mTreg) Foxp3highCD45RA-CD25highCD127low, FoxP3++CD45RA-CD25++CD127+/-) were cultured with IL-7 (10 ng/ml). Phenotype (CD39, Bcl-2, Stat5P, purinergic receptor P2X7R), suppression of the proliferation of autologous antiCD3 activated CD8+ T cells (CFSE stained) and cytokine profile (IL-17 production) of Treg were analyzed.

IL-7 abrogates memory T regulatory cell functions by modulation of CD39/ATP axis in vitro and in vivo in HIV infected and non-infected patients